synthesis and biological activity of trans-tiliroside derivatives as potent anti-diabetic agents
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2010
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Abstract
A set of novel trans-tiliroside derivatives were synthesized. The structures of the derivatives were identified by their IR, 1H-NMR, and MS spectra analysis. Their anti-diabetic activities were evaluated on the insulin resistant (IR) HepG2 cell model. As a result, compounds 7a, 7c, 7h, and trans-tiliroside exhibited significant glucose consumption-enhancing effects in IR-HepG2 cells compared with the positive control (metformin). This research provides useful clues for further design and discovery of anti-diabetic agents.
| Reference Key |
liu2010moleculessynthesis
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|---|---|
| Authors | ;Yi Liu;Hongwan Chu;Hongquan Duan;Yujin Zhu;Yanjun Zhang |
| Journal | Journal of ethnopharmacology |
| Year | 2010 |
| DOI |
10.3390/molecules15129174
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| URL | |
| Keywords | Keywords not found |
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