immunomodulatory role of phagocyte-derived chloramines involving lymphocyte glutathione

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ID: 137192
1993
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Abstract
This study shows that human lymphocytes markedly decrease chloramines (long-lived oxidants) generated by polymorphonuclear neutrophils (PMN) after stimulation by phorbol-myristate-acetate or opsonized zymosan. In a cell-free model, reduced glutathione (GSH) scavenged chloramines, giving rise to oxidized glutathione (GSSG). In the cell system, treatment of lymphocytes with autologous PMN-derived chloramines induced a profound decrease in their total and reduced glutathione (GSH) content and markedly inhibited their proliferate responses to concanavalin-A and, to a lesser extent, phytohaemagglutinin. It is concluded that (i) lymphocytes may play a defensive role against phagocyte-derived oxidative stress by scavenging chloramines, and (ii) as this effect which is mediated by GSH affects lymphocyte proliferative responses, it may help to elucidate the still obscure mechanisms of oxidative stress associated immunodeficiency.
Reference Key
witko-sarsat1993mediatorsimmunomodulatory Use this key to autocite in the manuscript while using SciMatic Manuscript Manager or Thesis Manager
Authors ;Véronique Witko-Sarsat;Anh Thu Nguyen;Béatrice Descamps-Latscha
Journal polyhedron
Year 1993
DOI
10.1155/S0962935193000328
URL
http://dx.doi.org/10.1155/S0962935193000328
Keywords
pathology

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