seroprevalence of human herpesvirus 8 and hepatitis c virus among drug users in shanghai, china

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ID: 137172
2014
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Abstract
To elucidate and compare the seroprevalence of human herpesvirus 8 (HHV8) and hepatitis C virus (HCV) among Chinese drug users, a cross-sectional study of 441 participants, was conducted in Shanghai, China, from 2012 through 2013. Seventy-seven (17.5%) participants were found to be positive for HHV8 antibodies, while 271 (61.5%) participants were positive for HCV. No significant association between HHV8 seropositivity and drug use characteristics, sexual behaviors, HCV, or syphilis was observed. In contrast, a statistically significant association between HCV seropositivity and injected drug history (OR, 2.18, 95% CI 1.41–3.37) was detected, whereas no statistically significant association between HCV seropositivity and syphilis infection (OR, 7.56, 95% CI 0.94–60.57) were observed. Pairwise comparisons showed no significant differences between latent and lytic antibodies regarding HCV and HHV8 serostatus. The study demonstrated a moderate but elevated prevalence of HHV8 infection among drug users. The discordance between HHV8 and HCV infections suggests that blood borne transmission of HHV8 might not be the predominant mode of transmission in this population, which is in contrast to HCV.
为阐明并比较中国吸毒人群中人类疱疹病毒8型（HHV8）与丙型肝炎病毒（HCV）的血清阳性率，2012年至2013年在中国上海开展了一项纳入441名受试者的横断面研究。结果显示，77名（17.5%）受试者HHV8抗体呈阳性，271名（61.5%）受试者HCV呈阳性。未观察到HHV8血清阳性与吸毒特征、性行为、HCV或梅毒之间存在显著关联。相比之下，HCV血清阳性与注射吸毒史之间存在具有统计学意义的关联（OR, 2.18, 95% CI 1.41–3.37），而HCV血清阳性与梅毒感染之间则未观察到具有统计学意义的关联（OR, 7.56, 95% CI 0.94–60.57）。两两比较显示，在HCV和HHV8血清学状态方面，潜伏期抗体与裂解期抗体之间无显著差异。该研究表明，吸毒人群中HHV8的感染率处于中等但偏高的水平。HHV8与HCV感染情况的不一致性提示，与HCV不同，经血液传播可能并非HHV8在该人群中的主要传播途径。
Reference Key
zhang2014virusesseroprevalence Use this key to autocite in the manuscript while using SciMatic Manuscript Manager or Thesis Manager
Authors ;Tiejun Zhang;Ying Liu;Yuyan Zhang;Jun Wang;Veenu Minhas;Charles Wood;Na He
Journal International journal of pharmaceutics
Year 2014
DOI
10.3390/v6062519
URL
http://www.mdpi.com/1999-4915/6/6/2519
Keywords
prevalence hepatitis c virus human herpesvirus 8

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