the novelty of human cancer/testis antigen encoding genes in evolution

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ID: 136841
2013
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Abstract
In order to be inherited in progeny generations, novel genes should originate in germ cells. Here, we suggest that the testes may play a special “catalyst” role in the birth and evolution of new genes. Cancer/testis antigen encoding genes (CT genes) are predominantly expressed both in testes and in a variety of tumors. By the criteria of evolutionary novelty, the CT genes are, indeed, novel genes. We performed homology searches for sequences similar to human CT in various animals and established that most of the CT genes are either found in humans only or are relatively recent in their origin. A majority of all human CT genes originated during or after the origin of Eutheria. These results suggest relatively recent origin of human CT genes and align with the hypothesis of the special role of the testes in the evolution of the gene families.
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dobrynin2013internationalthe Use this key to autocite in the manuscript while using SciMatic Manuscript Manager or Thesis Manager
Authors ;Pavel Dobrynin;Ekaterina Matyunina;S. V. Malov;A. P. Kozlov
Journal balıkesir medical journal
Year 2013
DOI
10.1155/2013/105108
URL
http://dx.doi.org/10.1155/2013/105108
Keywords
genetics

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