matrix metalloproteinase 2, 3, and 9 gene polymorphisms in women with rheumatoid arthritis

Clicks: 236
ID: 136599
2015
Free PDF
Article Quality & Performance Metrics
Overall Quality
Not rated
Combines reader engagement with the AI quality analysis. This article has not been analysed, so there is no overall score — reader engagement is measured and shown alongside.
AI Quality Assessment
Not analyzed
Readership in this journal
Steady

Ranked #20 of 34 articles by views in indian journal of chemical technology

Most read Least read

Bar heights use a square-root scale.

Mint this article as an NFT
Not yet minted

Create a permanent, verifiable on-chain record of this article on the Scimatic Network. The NFT is held in your Journament account, and you can withdraw it to your own wallet at any time.

5 SUSD one-off · no wallet required
Sign in to mint
Abstract
Aim. To study the promoter regions of the matrix metalloproteinase (MMP)2, MMP3, and MMP9 genes to assess their associations with the risk of rheumatoid arthritis (RA) and with the types of its clinical course in women. Subjects and methods. 162 female patients with RA and 329 women without this condition were examined. Polymorphisms in the gene promoter region for MMP2 (-1306 С→Т), MMP3 (-1171 5A→6А), and MMP9 (-1562 С→Т) were studied. Genotyping was carried out using the restriction fragment length polymorphism method. Results. In the RA group, the -1306TT genotype of MMP2 was significantly more frequently encountered and the 6A6A genotype was less frequently seen. In the seropositive RA group, the frequency of the -1306ТТ genotype of MMP2 was significantly higher than that in the healthy individuals. The significant differences shown for the entire group of patients with RA were preserved when they were divided into groups according to the presence or absence of rheumatoid nodules. Furthermore, the frequency of the homozygous -1306 genotypes of MMP2 was higher in both groups than in the healthy individuals. Conclusion. The presence of the allelic variants of the MMP genes may be one of the genetic factors that predispose to RA in women.
Reference Key
shevchenko2015matrix Use this key to autocite in the manuscript while using SciMatic Manuscript Manager or Thesis Manager
Authors ;A V Shevchenko;V I Konenkov;M A Korolev;Yu B Ubshaeva;V F Prokofiev
Journal indian journal of chemical technology
Year 2015
DOI
DOI not found
URL
https://ter-arkhiv.ru/0040-3660/article/view/31869
Keywords
Rheumatoid Arthritis polymorphism

Citations

No citations found. To add a citation, contact the admin at info@scimatic.org

Comments

No comments yet. Be the first to comment on this article.