tau depletion in app transgenic mice attenuates task-related hyperactivation of the hippocampus and differentially influences locomotor activity and spatial memory

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ID: 136444
2018
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Abstract
Hippocampal hyperactivity, ascribed to amyloid β (Aβ)-induced imbalances in neural excitation and inhibition, is found in patients with mild cognitive impairment, a prodromal stage of Alzheimer's disease (AD). To better understand the relationship between hippocampal hyperactivity and the molecular triggers of behavioral impairments in AD, we used Mn-enhanced MRI (MEMRI) to assess neuronal activity after subjecting mice to a task requiring spatial learning and memory. Depletion of endogenous tau in an amyloid precursor protein (APP) transgenic (J20) mouse line was shown to ameliorate hippocampal hyperactivity in J20 animals, tau depletion failed to reverse memory deficits associated with APP/Aβ overproduction. On the other hand, deletion of tau alleviated the hyperlocomotion displayed by APP transgenics, suggesting that the functional effects of Aβ-tau interactions reflect the temporal appearance of these molecules in individual brain areas.
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yoshikawa2018frontierstau Use this key to autocite in the manuscript while using SciMatic Manuscript Manager or Thesis Manager
Authors ;Misato Yoshikawa;Misato Yoshikawa;Yoshiyuki Soeda;Yoshiyuki Soeda;Makoto Michikawa;Osborne F. X. Almeida;Akihiko Takashima;Akihiko Takashima
Journal Journal of enzyme inhibition and medicinal chemistry
Year 2018
DOI
10.3389/fnins.2018.00124
URL
http://journal.frontiersin.org/article/10.3389/fnins.2018.00124/full
Keywords
hippocampus tau amyloid beta-peptides neuropsychiatry biological psychiatry

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