molecular characterization of severe and mild cases of influenza a (h1n1) 2009 strain from argentina caracterización molecular de cepas de influenza a (h1n1) 2009 de casos leves y graves de la argentina

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ID: 136084
2010
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Ranked #11 of 101 articles by views in proceedings on: 2016 ieee central america and panama student conference, conescapan 2016

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Abstract
While worldwide pandemic influenza A(H1N1) pdm case fatality rate (CFR) was 0.4%, Argentina's was 4.5%. A total of 34 strains from mild and severe cases were analyzed. A full genome sequencing was carried out on 26 of these, and a partial sequencing on the remaining eight. We observed no evidence that the high CFR can be attributed to direct virus changes. No evidence of re-assortment, mutations associated with resistance to antiviral drugs, or genetic drift that might contribute to virulence was observed. Although the mutation D225G associated with severity in the latest reports from the Ukraine and Norway is not observed among the Argentine strains, an amino acid change in the area (S206T) surrounding the HA receptor binding domain was observed, the same previously established worldwide.
Mientras que la tasa de letalidad (CFR) para (H1N1)pdm en todo el mundo era del 0.4%, en la Argentina la mortalidad observada fue de 4.5%. La secuenciación del genoma completo de 26 cepas de virus argentinos de influenza A (H1N1)pdm de casos leves y graves y de 8 cepas secuenciadas parcialmente no mostró evidencia de que la elevada tasa de letalidad se pueda atribuir directamente a cambios en el virus. No se encontraron hallazgos de recombinación, de mutaciones asociadas con la resistencia a los medicamentos antivirales ni de variaciones genéticas que puedan contribuir a la virulencia observada. Si bien la mutación D225G asociada con la gravedad, comunicada en informes procedentes de Ucrania y Noruega, no se ha encontrado en las cepas argentinas estudiadas, se ha observado un cambio aminoacídico en la región (S206T) en torno al dominio del sitio de unión al receptor en la HA, el mismo hallado en cepas distribuidas alrededor del mundo.
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baumeister2010medicinamolecular Use this key to autocite in the manuscript while using SciMatic Manuscript Manager or Thesis Manager
Authors ;Elsa Baumeister;Gustavo Palacios;Daniel Cisterna;Alexander Solovyov;Jeffrey Hui;Nazir Savji;Ana Valeria Bussetti;Ana Campos;Andrea Pontoriero;Omar J. Jabado;Craig Street;David L. Hirschberg;Raul Rabadan;Virginia Alonio;Viviana Molina;Stephen Hutchison;Michael Egholm;W. Ian Lipkin
Journal proceedings on: 2016 ieee central america and panama student conference, conescapan 2016
Year 2010
DOI
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URL
http://www.scielo.org.ar/scielo.php?script=sci_arttext&pid=S0025-76802010000600006
Keywords
argentina influenza h1n1 pdm

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