micrornas signatures, bioinformatics analysis of mirnas, mirna mimics and antagonists, and mirna therapeutics in osteosarcoma

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ID: 135729
2020
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Abstract
Abstract MicroRNAs (miRNAs) involved in key signaling pathways and aggressive phenotypes of osteosarcoma (OS) was discussed, including PI3K/AKT/MTOR, MTOR AND RAF-1 signaling, tumor suppressor P53- linked miRNAs, NOTCH- related miRNAs, miRNA -15/16 cluster, apoptosis related miRNAs, invasion-metastasis-related miRNAs, and 14Q32-associated miRNAs cluster. Herrin, we discussed insights into the targeted therapies including miRNAs (i.e., tumor-suppressive miRNAs and oncomiRNAs). Using bioinformatics tools, the interaction network of all OS-associated miRNAs and their targets was also depicted.
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Authors ;Babak Otoukesh;Mehdi Abbasi;Habib-o-Lah Gorgani;Hossein Farahini;Mehdi Moghtadaei;Bahram Boddouhi;Peyman Kaghazian;Shayan Hosseinzadeh;Atefe Alaee
Journal management and economics review
Year 2020
DOI
10.1186/s12935-020-01342-4
URL
http://link.springer.com/article/10.1186/s12935-020-01342-4
Keywords
osteosarcoma micrornas targets Oncology including cancer and carcinogenscytology tumors

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