generation and characterization of a human induced pluripotent stem (ips) cell line derived from an acute myeloid leukemia patient evolving from primary myelofibrosis carrying the calr 52 bp deletion and the asxl1 p.r693x mutation
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2017
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Abstract
Peripheral blood sample was donated by a 61 years old female patient diagnosed with acute myeloid leukemia secondary to a primary myelofibrosis harboring the 52-bp deletion in the CALR gene (c.1092_1143del, p.L367fs*46) and the R693X mutation in the ASXL1 gene (c.2077C>T, p.R693X). CD34+ cells were isolated from the sample and subjected to the reprogramming procedure by using the Sendai virus carrying the reprogramming factors Oct3/4, Sox2, Klf4 and c-Myc. iPS colonies generated retained the original mutations and displayed all the features of bona fide iPS cells.
| Reference Key |
limia2017stemgeneration
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| Authors | ;Cintia E. Gomez Limia;Sylvie Devalle;Marcelo Reis;Jaroslaw Sochacki;Mayra Carneiro;Rodrigo Madeiro da Costa;Mariana D'Andrea;Telma Padilha;Ilana R. Zalcberg;Cristiana Solza;Adelmo Daumas;Stevens Rehen;Bárbara Monte-Mór;Martín H. Bonamino |
| Journal | journal of energy chemistry |
| Year | 2017 |
| DOI |
10.1016/j.scr.2017.08.006
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