ultra sensitivity silicon-based photonic crystal microcavity biosensors for plasma protein detection in patients with pancreatic cancer
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2020
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Abstract
Defect-engineered photonic crystal (PC) microcavities were fabricated by UV photolithography and their corresponding sensitivities to biomarkers in patient plasma samples were compared for different resonant microcavity characteristics of quality factor Q and biomarker fill fraction. Three different biomarkers in plasma from pancreatic cancer patients were experimentally detected by conventional L13 defect-engineered microcavities without nanoholes and higher sensitivity L13 PC microcavities with nanoholes. 8.8 femto-molar (0.334 pg/mL) concentration of pancreatic cancer biomarker in patient plasma samples was experimentally detected which are 50 times dilution than ELISA in a PC microcavity with high quality factor and high analyte fill fraction.
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yang2020micromachinesultra
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| Authors | ;Chun-Ju Yang;Hai Yan;Naimei Tang;Yi Zou;Yas Al-Hadeethi;Xiaochuan Xu;Hamed Dalir;Ray T. Chen |
| Journal | chemistryopen |
| Year | 2020 |
| DOI |
10.3390/mi11030282
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