the presence of morphine as heroin metabolites in placental tissue and fetus: case report

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ID: 134750
2014
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Abstract
Introduction. Females who have developed addiction to heroin also abuse it during pregnancy. Heroin can be detected in the fetal blood-flow already an hour after maternal i.v. injection. Heroin metabolites enter the fetal blood-flow through the placental barrier by passive transport. Case Outline. We present a 27-year-old female in the 5th month of pregnancy that had a miscarriage. Chemo-toxicological analysis (gas chromatography with mass spectrometry - GC/MS), showed the presence of morphine in the fetal liver (31.92 ng/g), placenta (27.94 ng/g) and meconium (136.33 ng/g). The analysis did not show the presence of 6-monoacetylmorphine. Conclusion. In all cases when the autopsy of fetus or newborn is performed, with mother suspected as i.v. heroin abuser, chemotoxicological placental analysis, placenta and meconium should be also done. [Projekat Ministarstva nauke Republike Srbije, br. 45005]
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slobodan2014srpskithe Use this key to autocite in the manuscript while using SciMatic Manuscript Manager or Thesis Manager
Authors Nikolić Slobodan, Micić-Labudović Jelena, Lukić Vera, Živković Vladimir
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Journal Journal of Asian natural products research
Year 2014
DOI
10.2298/SARH1410610N
URL
http://www.doiserbia.nb.rs/img/doi/0370-8179/2014/0370-81791410610N.pdf
Keywords
placenta heroin morphine

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