the fibroblast growth factor receptors in breast cancer: from oncogenesis to better treatments

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ID: 134489
2020
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Abstract
Breast cancer (BC) is the most frequent form of malignancy and second only to lung cancer as cause of deaths in women. Notwithstanding many progresses made in the field, metastatic BC has a very poor prognosis. As therapies are becoming more personalized to meet the needs of patients, a better knowledge of the molecular biology leading to the disease unfolds the possibility to project more precise compounds or antibodies targeting definite alteration at the molecular level and functioning on such cancer-causing molecules expressed in cancer cells of patients, or present as antigens on the surface of cancer cell membranes. Fibroblast growth factor receptor (FGFR) is one of such druggable targets, activated by its own ligands -namely the Fibroblast Growth Factors (FGFs). This pathway provides a vast range of interesting molecular targets pursued at different levels of clinical investigation. Herein we provide an update on the knowledge of genetic alterations of the receptors in breast cancer, their role in tumorigenesis and the most recent drugs against this particular receptor for the treatment of the disease.
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sobhani2020internationalthe Use this key to autocite in the manuscript while using SciMatic Manuscript Manager or Thesis Manager
Authors ;Navid Sobhani;Chunmei Fan;Pedro O. Flores-Villanueva;Daniele Generali;Yong Li
Journal Intertax
Year 2020
DOI
10.3390/ijms21062011
URL
https://www.mdpi.com/1422-0067/21/6/2011
Keywords
metastatic breast cancer targeted therapies

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