derangements in bone mineral parameters and bone mineral density in south indian subjects on antiepileptic medications

Clicks: 317
ID: 134348
2014
Free PDF
Article Quality & Performance Metrics
Overall Quality
Not rated
Combines reader engagement with the AI quality analysis. This article has not been analysed, so there is no overall score — reader engagement is measured and shown alongside.
AI Quality Assessment
Not analyzed
Readership in this journal
Steady

Ranked #22 of 113 articles by views in Journal of global antimicrobial resistance

Most read Least read

Bar heights use a square-root scale.

Mint this article as an NFT
Not yet minted

Create a permanent, verifiable on-chain record of this article on the Scimatic Network. The NFT is held in your Journament account, and you can withdraw it to your own wallet at any time.

5 SUSD one-off · no wallet required
Sign in to mint
Abstract
Background: Although there are reports describing the association of alternations of bone and mineral metabolism in epileptic patients with long-term anticonvulsant therapy, there are only limited Indian studies which have looked at this aspect. Objectives: This study was done to compare the prevalence of changes in bone mineral parameters and bone mineral density (BMD) in ambulant individuals on long-term anticonvulsant therapy with age- and body mass index (BMI)-matched healthy controls. Materials and Methods: There were 55 men (on medications for more than 6 months) and age- and BMI-matched 53 controls. Drug history, dietary calcium intake (DCI), and duration of sunlight exposure were recorded. Bone mineral parameters and BMD were measured. Results: The control group had a significantly higher daily DCI with mean ± SD of 396 ± 91 mg versus 326 ± 101 mg (P = 0.007) and more sunlight exposure of 234 ± 81 vs 167 ± 69 min (P = 0.05). BMD at the femoral neck was significantly lower in cases (0.783 ± 0.105 g/cm 2 ) when compared to controls (0.819 ± 0.114 g/cm 2 ). Majority of the patients (61%) had low femoral neck BMD (P = 0.04). There was no significant difference in the proportion of subjects with vitamin D deficiency (<20 ng/mL) between cases (n = 32) and controls (n = 37) (P = 0.234). Conclusions: Vitamin D deficiency was seen in both the groups in equal proportions, highlighting the existence of a high prevalence of this problem in India. Low femoral neck BMD found in cases may stress the need for supplementing calcium and treating vitamin D deficiency in this specific group. However, the benefit of such intervention has to be studied in a larger proportion of epileptic patients.
Reference Key
koshy2014annalsderangements Use this key to autocite in the manuscript while using SciMatic Manuscript Manager or Thesis Manager
Authors George Koshy, Ron Thomas Varghese, Dukhabandhu Naik, Hesargatta Shyamsunder Asha, Nihal Thomas, Mandalam Subramaniam Seshadri, Mathew Alexander, Maya Thomas, Sanjith Aaron, Thomas Vizhalil Paul
Are you one of these authors? Claim your profile
Journal Journal of global antimicrobial resistance
Year 2014
DOI
10.4103/0972-2327.138489
URL
http://www.annalsofian.org/article.asp?issn=0972-2327;year=2014;volume=17;issue=3;spage=272;epage=276;aulast=Koshy
Keywords
epilepsy bone mineral density diseases of the nervous system

Citations

No citations found. To add a citation, contact the admin at info@scimatic.org

Comments

No comments yet. Be the first to comment on this article.