molecular properties of water-unextractable proteoglycans from hypsizygus marmoreus and their in vitro immunomodulatory activities
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ID: 134068
2011
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Abstract
Four proteoglycans were sequentially extracted from Hypsizygus marmoreus using 0.1 M NaOH (alkali-soluble proteoglycans [F1] and alkali-insoluble proteoglycans [F3]) and 0.1 M HCl (acid-soluble proteoglycans [F2] and acid-insoluble proteoglycans [F4]), and their structures and immunomodulatory activities were investigated. The proteoglycans were found to contain carbohydrates (19.8–82.4%) with various amounts of proteins (7.7–67.3%), and glucose was the major monosaccharide unit present, along with trace amounts of galactose. The molecular weights (Mw) and the radius of gyration (Rg) of these proteoglycans showed ranges of 16 × 104–19,545 × 104 g/mol and 35–148 nm, respectively, showing significant variations in their molecular conformations. The backbones of F1 and F2 were mainly connected through a-(1→3), (1→4) and b-(1→6)-glycosidic linkages with some branches. The F1 and F2 proteoglycans significantly stimulated Raw264.7 cells to release nitric oxide (NO), prostaglandin E2 (PGE2) and various cytokines, such as IL-1β, TNF-α and IL-6 by inducing their mRNA expressions.
| Reference Key |
chae2011moleculesmolecular
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| Authors | ;Hee Mun Chae;Hong Hui Bao;Mehdi Tarbasa;Sang Guan You |
| Journal | Journal of ethnopharmacology |
| Year | 2011 |
| DOI |
10.3390/molecules17010207
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