how useful are monogenic rodent models for the study of human non-alcoholic fatty liver disease?

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ID: 133929
2016
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Abstract
Improving understanding of the genetic basis of human non-alcoholic fatty liver disease (NAFLD) has the potential to facilitate risk stratification of affected patients, permit personalised treatment, and inform development of new therapeutic strategies. Animal models have been widely used to interrogate the pathophysiology of, and genetic predisposition, to NAFLD. Nevertheless considerable interspecies differences in intermediary metabolism potentially limits the extent to which results can be extrapolated to humans. For example, human genome-wide association studies have identified polymorphisms in PNPLA3 and TM6SF2 as the two most prevalent determinants of susceptibility to NAFLD and its inflammatory component (NASH), but animal models of these mutations have had only variable success in recapitulating this link. In this review we critically appraise selected murine monogenic models of NAFLD, NASH, and hepatocellular carcinoma (HCC) with a focus on how closely they mirror human disease.
Reference Key
mann2016frontiershow Use this key to autocite in the manuscript while using SciMatic Manuscript Manager or Thesis Manager
Authors ;Jake Peter Mann;Robert Kenneth Semple;Robert Kenneth Semple;Matthew J Armstrong;Matthew J Armstrong
Journal aip advances
Year 2016
DOI
10.3389/fendo.2016.00145
URL
http://journal.frontiersin.org/Journal/10.3389/fendo.2016.00145/full
Keywords
metabolic syndrome animal model steatosis clinical endocrinology steatohepatitisdiseases of the endocrine glands

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