preoperative serum levels of soluble endoglin for prediction of recurrence in stage iii colorectal cancer patients

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ID: 133773
2012
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Abstract
Background: To evaluate the clinical usefulness of serum levels of soluble form of endoglin in stage III colorectal adenocarcinomas (CRC) patients for detection of recurrence. Methods: The case-control study consisted of 80 stage III CRC patients who underwent surgery with curative intent and 70 age-and sex-matched healthy volunteers. Serum levels of soluble form of endoglin (sol-end) were measured in both groups. Also, predictive factors of recurrence were evaluated using multivariate analyses. Results: Serum levels of sol-end in stage III CRC patients were significantly higher than those in controls. There was not a significant association between serum levels of sol-end and clinicopathological features in CRC patients. Multivariate regression analysis showed the LNR (hazard ratio, 2.54; 95% CI, 1.46–4.34; p < 0.001), to be significant independent factors to estimate local recurrence in stage III CRC patients. Conclusion: Preoperative serum levels of sol-end do not seem useful as a marker for detection of recurrence in stage III CRC patients.
Reference Key
gomceli2012actapreoperative Use this key to autocite in the manuscript while using SciMatic Manuscript Manager or Thesis Manager
Authors Ismail Gomceli, Mesut Tez, Erdal B. Bostanci, Nesrin Turhan, Ahu S. Kemik, Musa Akoglu
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Journal journal of the brazilian chemical society
Year 2012
DOI
10.14712/18059694.2015.58
URL
https://actamedica.lfhk.cuni.cz/55/2/0074/
Keywords
Cancer colon rectum

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