preoperative serum levels of soluble endoglin for prediction of recurrence in stage iii colorectal cancer patients
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2012
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Abstract
Background: To evaluate the clinical usefulness of serum levels of soluble form of endoglin in stage III colorectal adenocarcinomas (CRC) patients for detection of recurrence. Methods: The case-control study consisted of 80 stage III CRC patients who underwent surgery with curative intent and 70 age-and sex-matched healthy volunteers. Serum levels of soluble form of endoglin (sol-end) were measured in both groups. Also, predictive factors of recurrence were evaluated using multivariate analyses. Results: Serum levels of sol-end in stage III CRC patients were significantly higher than those in controls. There was not a significant association between serum levels of sol-end and clinicopathological features in CRC patients. Multivariate regression analysis showed the LNR (hazard ratio, 2.54; 95% CI, 1.46–4.34; p < 0.001), to be significant independent factors to estimate local recurrence in stage III CRC patients. Conclusion: Preoperative serum levels of sol-end do not seem useful as a marker for detection of recurrence in stage III CRC patients.
| Reference Key |
gomceli2012actapreoperative
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|---|---|
| Authors | ;Ismail Gomceli;Mesut Tez;Erdal B. Bostanci;Nesrin Turhan;Ahu S. Kemik;Musa Akoglu |
| Journal | journal of the brazilian chemical society |
| Year | 2012 |
| DOI |
10.14712/18059694.2015.58
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| URL | |
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