dissecting mechanisms of brain aging by studying the intrinsic excitability of neurons

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ID: 133732
2015
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Abstract
Several studies using vertebrate and invertebrate animal models have shown aging associated changes in brain function. Importantly, changes in soma size, loss or regression of dendrites and dendritic spines and alterations in the expression of neurotransmitter receptors in specific neurons were described. Despite this understanding, how aging impacts intrinsic properties of individual neurons or circuits that govern a defined behavior is yet to be determined. Here we discuss current understanding of specific electrophysiological changes in individual neurons and circuits during aging.
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erizzo2015frontiersdissecting Use this key to autocite in the manuscript while using SciMatic Manuscript Manager or Thesis Manager
Authors ;Valerio eRizzo;Jeffrey eRichman;Sathyanarayanan ePuthanveettil
Journal Frontiers in chemistry
Year 2015
DOI
10.3389/fnagi.2014.00337
URL
http://journal.frontiersin.org/Journal/10.3389/fnagi.2014.00337/full
Keywords
aging electrophysiology synaptic transmission neuropsychiatry biological psychiatry single neuron

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