y-box protein-1 regulates the expression of collagen i in hepatic progenitor cells via pdgfr-β/erk/p90rsk signalling
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ID: 133204
2017
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Abstract
Y-box protein-1 (YB-1) is a highly conserved transcription factor that is involved in multiple biological processes via transcriptional regulation of several genes, including p53, cyclin D1, and EGFR. YB-1 has been reported to be overexpressed in injured livers. This study aims to explore the functions of YB-1 in hepatic progenitor cells (HPCs). Herein, chromatin immunoprecipitation sequencing (ChIP-sequencing) and RNA-sequencing assays identified that YB-1 participated in the biological adhesion process and ECM-receptor interactions in HPCs. Further study demonstrated that YB-1 modulated the expression of extracellular matrix components in HPCs. ChIP-sequencing assays established that PDGFR-β was a target gene of YB-1, and luciferase reporter assays confirmed that YB-1 negatively regulated PDGFR-β promoter activity in HPCs. In addition, PDGFR-β can regulate the expression of collagen I through ERK/p90RSK signalling, and disruption of the signalling pathway with a PDGFR-β inhibitor or ERK1/2 inhibitor abolished the regulatory effect of PDGFR-β on collagen I expression in HPCs. Conclusively, YB-1 can modulate the expression of collagen I in HPCs via direct binding to the PDGFR-β promoter, negatively regulating its expression. In addition, the ERK/p90RSK axis serves as the downstream signalling pathway of PDGFR-β.
| Reference Key |
li2017stemy-box
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|---|---|
| Authors | ;Fei Li;Zhenzeng Ma;Heng Liu;Qidi Zhang;Xiaobo Cai;Ying Qu;Mingyi Xu;Lungen Lu |
| Journal | journal of experimental psychology: general |
| Year | 2017 |
| DOI |
10.1155/2017/6193106
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| URL | |
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