regulation of apoptosis during porcine circovirus type 2 infection

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ID: 133020
2018
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Ranked #691 of 875 articles by views in journal of magnetic resonance (san diego, calif : 1997)

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Abstract
Apoptosis, an indispensable innate immune mechanism, regulates cellular homeostasis by removing unnecessary or damaged cells. It contains three signaling pathways: the mitochondria-mediated pathway, the death receptor pathway and the endoplasmic reticulum pathway. The importance of apoptosis in host defenses is stressed by the observation that multiple viruses have evolved various strategies to inhibit apoptosis, thereby blunting the host immune responses and promoting viral propagation. Porcine Circovirus type 2 (PCV2) utilizes various strategies to induce or inhibit programmed cell death. In this article, we review the latest research progress of the apoptosis mechanisms during infection with PCV2, including several proteins of PCV2 regulate apoptosis via interacting with host proteins and multiple signaling pathways involved in PCV2-induced apoptosis, which provides scientific basis for the pathogenesis and prevention of PCV2.
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Authors ;Yuhong Pan;Yuhong Pan;Yuhong Pan;Pengfei Li;Pengfei Li;Pengfei Li;Renyong Jia;Renyong Jia;Renyong Jia;Mingshu Wang;Mingshu Wang;Mingshu Wang;Zhongqiong Yin;Anchun Cheng;Anchun Cheng;Anchun Cheng
Journal journal of magnetic resonance (san diego, calif : 1997)
Year 2018
DOI
10.3389/fmicb.2018.02086
URL
https://www.frontiersin.org/article/10.3389/fmicb.2018.02086/full
Keywords
apoptosis signaling pathway pcv2

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