overseas processing of dried blood spots for timely diagnosis of hiv in haitian infants diagnóstico oportuno del vih en niños haitianos mediante el procesamiento en el extranjero de muestras de sangre seca

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ID: 132370
2008
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Abstract
OBJECTIVE: To determine the feasibility of sending dried blood spots (DBS) to an overseas processing center for the diagnosis of HIV infection in infants in rural Haiti. METHODS: The program took place in the Central Department of Haiti. Children under 18 months of age who were born to an HIV-infected mother or who had a positive HIV antibody test had blood collected on filter paper. Once dry, specimens were labeled with a unique identifying number, placed in sealed gas-impermeable envelopes containing a desiccant, stored at room temperature, and mailed to a commercial laboratory in The Netherlands, where blood was eluted from the filter paper and analyzed by the RetinaTM rainbow HIV-1 RNA assay. Infants were tested at 1 month of age and again at 4 months of age. RESULTS: The DBS protocol was easily scaled up. During the study period, 138 infants had HIV status confirmed; 15 of them were found to be HIV infected and were enrolled in appropriate HIV care, and 123 were confirmed to be HIV uninfected, avoiding unnecessary prophylactic antibiotics and providing reassurance to caregivers. CONCLUSION: Central, overseas processing of DBS is a feasible solution for the timely diagnosis of HIV infection in infants where local capacity is unavailable. Regional processing centers for DBS could improve the access of millions of children in Latin America and the Caribbean to timely diagnosis of HIV infection.
OBJETIVO: Determinar la factibilidad de enviar muestras de sangre seca (MSS) a un centro en el extranjero para el diagnóstico de la infección por el VIH en niños de zonas rurales de Haití. MÉTODOS: El programa se realizó en el Departamento Central de Haití. Se tomó una muestra de sangre en papel de filtro de los niños menores de 18 meses nacidos de madres infectadas con el VIH o que tuvieran una prueba positiva de anticuerpos contra el VIH. Una vez secas, las muestras se etiquetaron con un número de identificación único, se colocaron en sobres sellados impermeable a gases con desecante, se almacenaron a temperatura ambiente y se enviaron por correo a un laboratorio comercial en los Países Bajos, donde se eluyó la sangre del papel de filtro y se analizó mediante el sistema RetinaTM Rainbow para la detección de ARN del VIH-1. Las pruebas se realizaron a los niños de 1 mes y se repitió a los 4 meses de edad. RESULTADOS: El procedimiento de MSS se llevó fácilmente a una escala mayor. En el período de estudio se confirmó el diagnóstico de 138 niños: 15 de ellos estaban infectados y recibieron los cuidados apropiados; 123 niños no tenían la infección, lo que evitó aplicar innecesariamente el tratamiento antibiótico profiláctico y el personal de salud sintió mayor confianza. CONCLUSIONES: El procesamiento centralizado de MSS en el extranjero es una solución factible para el diagnóstico oportuno de la infección por el VIH en niños cuando no hay capacidad local de diagnóstico. Centros regionales para el procesamiento de MSS podrían mejorar el acceso de millones de niños de América Latina y el Caribe al diagnóstico oportuno de esta infección.
Reference Key
ivers2008revistaoverseas Use this key to autocite in the manuscript while using SciMatic Manuscript Manager or Thesis Manager
Authors ;Louise C. Ivers;Mary Catherine Smith Fawzi;Julie Mann;Jean-Gregory Jerome;Maxi Raymonville;Joia S. Mukherjee
Journal communications on pure and applied analysis
Year 2008
DOI
DOI not found
URL
http://www.scielosp.org/scielo.php?script=sci_arttext&pid=S1020-49892008001100005
Keywords
haiti poverty areas tropical medicinepublic aspects of medicine hiv serodiagnosis

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