synthesis and antimicrobial studies of furyl based new bispyrazolines linked via aliphatic chains

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ID: 132342
2017
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Abstract
The symmetrical bisheterocycles built around varying lengths aliphatic linkers have been synthesized from the easy cyclization reactions of bischalcones with phenyl hydrazine by refluxing in dry EtOH and glacial acetic acid medium. The intermediates in turn were prepared in the good yields from O-alkylation of hydroxy substituted chalcone with suitable 1,ω-dibromoalkanes in the presence of anhydrous K2CO3, dry acetone and Bu4N+I− as PTC. The chalcone was obtained from the Claisen–Schmidt condensation reaction of p-hydroxyacetophenone with 2-furfuraldehyde. The structures of bischalcones and bispyrazolines were fully characterized by using various spectroscopic techniques including IR, 1H NMR, 13C NMR & Mass (ESI) and purity of these products were confirmed from their elemental analysis results. The newly prepared compounds were also screened for their antimicrobial activities against seven bacterial and five fungal strains by using serial tube dilution method. Some of the compounds exhibited significant activities against the tested microorganisms.
Reference Key
yusuf2017journalsynthesis Use this key to autocite in the manuscript while using SciMatic Manuscript Manager or Thesis Manager
Authors ;Mohamad Yusuf;Indu Solanki
Journal zaporožskij medicinskij Žurnal
Year 2017
DOI
10.1016/j.jscs.2015.02.002
URL
http://www.sciencedirect.com/science/article/pii/S1319610315000162
Keywords
antibacterial antifungal mic

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