is sleep disruption a cause or consequence of alzheimer’s disease? reviewing its possible role as a biomarker

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ID: 132338
2020
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Abstract
In recent years, the idea that sleep is critical for cognitive processing has gained strength. Alzheimer’s disease (AD) is the most common form of dementia worldwide and presents a high prevalence of sleep disturbances. However, it is difficult to establish causal relations, since a vicious circle emerges between different aspects of the disease. Nowadays, we know that sleep is crucial to consolidate memory and to remove the excess of beta-amyloid and hyperphosphorilated tau accumulated in AD patients’ brains. In this review, we discuss how sleep disturbances often precede in years some pathological traits, as well as cognitive decline, in AD. We describe the relevance of sleep to memory consolidation, focusing on changes in sleep patterns in AD in contrast to normal aging. We also analyze whether sleep alterations could be useful biomarkers to predict the risk of developing AD and we compile some sleep-related proposed biomarkers. The relevance of the analysis of the sleep microstructure is highlighted to detect specific oscillatory patterns that could be useful as AD biomarkers.
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lloret2020internationalis Use this key to autocite in the manuscript while using SciMatic Manuscript Manager or Thesis Manager
Authors ;Maria-Angeles Lloret;Ana Cervera-Ferri;Mariana Nepomuceno;Paloma Monllor;Daniel Esteve;Ana Lloret
Journal Intertax
Year 2020
DOI
10.3390/ijms21031168
URL
https://www.mdpi.com/1422-0067/21/3/1168
Keywords
spindles nrem rem sws

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