systemic cat scratch disease

Clicks: 8
ID: 132264
2006
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Ranked #244 of 246 articles by views in Bioorganic & medicinal chemistry letters

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Abstract
Systemic cat scratch disease (CSD) is often associated with prolonged fever and microabscesses in the liver and/or spleen. We report a case of systemic CSD with hepatic, splenic and renal involvement in an aboriginal child in Taiwan. A previously healthy 9-year-old girl had an intermittent fever for about 17 days, and complained of abdominal pain, headache and weight loss. Abdominal computed tomography showed multiple tiny hypodense nodular lesions in the spleen and both kidneys. Laparotomy revealed multiple soft, whitishtan lesions on the surface of the liver and spleen. Histopathologic examination of a biopsy specimen of the spleen showed necrotizing granulomatous inflammation with central necrosis surrounded by epithelioid cells and occasional Langhans' giant cells, strongly suggestive of Bartonella henselae infection. History revealed close contact with a cat. B. henselae DNA was detected by polymerase chain reaction in the tissue specimen, and the single antibody titer against B. henselae was greater than 1:2048. These results confirmed the diagnosis of visceral CSD caused by B. henselae. The patient's symptoms resolved after treatment with rifampin and tetracycline. This case illustrates the need for inclusion of systemic CSD in patients with fever of unknown origin and abdominal pain.
Reference Key
liao2006journalsystemic Use this key to autocite in the manuscript while using SciMatic Manuscript Manager or Thesis Manager
Authors ;Hui-Min Liao;Fu-Yuan Huang;Hsin Chi;Nieu-Lu Wang;Be-Fong Chen
Journal Bioorganic & medicinal chemistry letters
Year 2006
DOI
10.1016/S0929-6646(09)60168-6
URL
http://www.sciencedirect.com/science/article/pii/S0929664609601686
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