mir-200a suppresses the proliferation and metastasis in pancreatic ductal adenocarcinoma through downregulation of dek gene

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ID: 132015
2016
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Abstract
MiR-200a has been reported to be able to suppress the epithelial-mesenchymal transition process in pancreatic cancer stem cells, suggesting that miR-200a could suppress the metastasis of pancreatic ductal adenocarcinoma (PDAC). However, its role in proliferation and metastasis of PDAC and the underlying mechanism by which miR-200a works in PDAC have not been elucidated. In our study, we for the first time identified that DEK gene is a direct downstream target of miR-200a. It was found that overexpression of miR-200a decreased DEK expression, suppressing the proliferation, migration, and invasion of PDAC cells. Meanwhile, knockdown of miR-200a can increase DEK level, promoting the proliferation, migration, and invasion of PDAC cells. Our study demonstrated that miR-200a suppresses the metastasis in pancreatic PDAC through downregulation of DEK, suggesting that miR-200a may be used as a novel potential marker in prediction of metastasis of PDAC.
Reference Key
wu2016translationalmir-200a Use this key to autocite in the manuscript while using SciMatic Manuscript Manager or Thesis Manager
Authors ;Xiaoyu Wu;Guannan Wu;Zhenfeng Wu;Xuequan Yao;Gang Li
Journal advances in acoustics and vibration
Year 2016
DOI
10.1016/j.tranon.2015.11.005
URL
http://www.sciencedirect.com/science/article/pii/S1936523315300255
Keywords
neoplasms Oncology including cancer and carcinogens tumors

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