angiogenic and vasculogenic factors in the vitreous from patients with proliferative diabetic retinopathy

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ID: 131912
2013
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Abstract
This study was conducted to determine levels of angiogenic and endothelial progenitor cell mobilizing (vasculogenic) factors in vitreous fluid from proliferative diabetic retinopathy (PDR) patients and correlate their levels with clinical disease activity. Vascular endothelial growth factor (VEGF), soluble vascular endothelial growth factor receptor-2 (sVEGFR-2), stem cell factor (SCF), soluble c-kit (s-kit), endothelial nitric oxide synthase (eNOS), and prostaglandin E2 (PGE2) levels were measured by ELISA in vitreous samples from 34 PDR and 15 nondiabetic patients. eNOS was not detected. VEGF, sVEGFR-2, SCF, and s-kit levels were significantly higher in PDR with active neovascularization compared with quiescent PDR and nondiabetic patients (; 0.007; 0.001; , resp.). In contrast, PGE2 levels were significantly higher in nondiabetic patients compared with PDR patients (). There were significant correlations between levels of sVEGFR-2 versus SCF (, ), sVEGFR-2 versus s-kit (, ), and SCF versus s-kit (, ). Our findings suggest that upregulation of VEGF, sVEGFR-2, SCF, and s-kit supports the contributions of angiogenesis and vasculogenesis in pathogenesis of PDR.
Reference Key
el-asrar2013journalangiogenic Use this key to autocite in the manuscript while using SciMatic Manuscript Manager or Thesis Manager
Authors ;Ahmed M. Abu El-Asrar;Mohd Imtiaz Nawaz;Dustan Kangave;Mohammed Mairaj Siddiquei;Karel Geboes
Journal applied computer science
Year 2013
DOI
10.1155/2013/539658
URL
http://dx.doi.org/10.1155/2013/539658
Keywords
clinical endocrinology diseases of the endocrine glands

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