supramolecular encapsulation of vitamin b6 by macrocyclic nanocontainer cucurbit[7]uril
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ID: 131184
2015
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Abstract
A pharmaceutically and biologically relevant molecule, pyridoxine hydrochloride (vitamin B6), was encapsulated inside the cavity of a molecular container, cucurbit[7]uril (CB[7]), in aqueous solution. The CB[7] based “nanocapsule” of vitamin B6 has been investigated for the first time, via 1H NMR and UV-visible spectroscopic titrations (including Job’s plot) and ab initio molecular modeling. The results have demonstrated that vitamin B6 forms stable host-guest complexes within CB[7] in 1 : 1 stoichiometry, with a binding affinity of (4.0±0.5)×103 M−1. Such a nanocapsule could potentially find application in vitamin B6 formulation for the purpose of enhancing the stability, absorption, and delivery of this important vitamin.
| Reference Key |
li2015journalsupramolecular
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|---|---|
| Authors | ;Wanying Li;Shengke Li;Ian W. Wyman;Donal H. Macartney;Qingwen Zhang;Ying Zheng;Ruibing Wang |
| Journal | reproductive biology and endocrinology |
| Year | 2015 |
| DOI |
10.1155/2015/574013
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| URL | |
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