synthesis of plasmepsin ii inhibitors – potential antimalarial agents
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ID: 131166
2003
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Abstract
A new series of plasmepsin II (PM II) inhibitors has been prepared based on 4-aminopiperidine-tert-butyl-carbamate (1). These compounds might be useful as antimalarial drugs acting via a new mechanism, and therefore be less susceptible to parasite resistance now often observed with current antimalarial therapies. Some of the final compounds prepared exhibited encouraging inhibitory activity towards PM II.
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boss2003moleculessynthesis
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| Authors | ;Christoph Boss;Marianne Huerzeler;Reto Mueller |
| Journal | Journal of ethnopharmacology |
| Year | 2003 |
| DOI |
10.3390/80700556
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