lack of association between the tnf-α -308 (g/a) genetic polymorphism and periodontal disease in brazilians
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ID: 131091
2008
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Abstract
This study evaluated the frequency of the tumor necrosis factor-alpha (TNF-α) -308 G/A polymorphism in Brazilians with periodontal health (PH = 51), chronic periodontitis (CP = 74) and generalized aggressive periodontitis (GAgP = 38). Human DNA was obtained from mouthwash samples and TNF-α genotyping was performed by PCR and RFLP analyses. Differences in clinical and genetic parameters among groups were sought by Kruskal-Wallis, χ² and Fisher's exact tests. The allele -308G was detected in 91.7%, whereas the allele -308A was found in 35.4% of all subjects. No significant differences were observed in the frequency of these alleles (χ² = 2.610, p > 0.05) and the genotypes G/G, G/A, and A/A (χ² = 2.547, p = 0.636) among groups. The data suggest that the TNF-α -308 G/A polymorphism is not associated with periodontitis in this Brazilian population.
| Reference Key |
menezes2008brazilianlack
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|---|---|
| Authors | ;Natascha Giovannetti de Menezes;Ana Paula Vieira Colombo |
| Journal | journal of information and computational science |
| Year | 2008 |
| DOI |
10.1590/S1806-83242008000400007
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