An arsenal of methods for the experimental characterization of intrinsically disordered proteins - How to choose and combine them?

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ID: 13065
2019
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Ranked #277 of 642 articles by views in archives of biochemistry and biophysics

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Abstract
In this review, we detail the most common experimental approaches to assess and characterize protein intrinsic structural disorder, with the notable exception of NMR and EPR spectroscopy, two ideally suited approaches that will be described in depth in two other reviews within this special issue. We discuss the advantages, the limitations, as well as the caveats of the various methods. We also describe less common and more demanding approaches that enable achieving further insights into the conformational properties of IDPs. Finally, we present recent developments that have enabled assessment of structural disorder in living cells, and discuss the currently available methods to model IDPs as conformational ensembles.
Reference Key
schramm2019anarchives Use this key to autocite in the manuscript while using SciMatic Manuscript Manager or Thesis Manager
Authors Schramm, Antoine;Bignon, Christophe;Brocca, Stefania;Grandori, Rita;Santambrogio, Carlo;Longhi, Sonia;
Journal archives of biochemistry and biophysics
Year 2019
DOI
S0003-9861(19)30452-7
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