h2so4-silica catalyzed one-pot and efficient synthesis of dihydropyrimidinones under solvent-free conditions
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ID: 130597
2011
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Abstract
H2SO4-Silica efficiently catalyzes the three-component condensation reaction of aldehydes, 1,3-dicarbonyl compounds and urea/thiourea under solvent free conditions to afford the corresponding dihydropyrimidinones and thio-derivatives in high yields. Compared to the classical Biginelli reaction conditions, this new method consistently has the advantage of giving good yields and requiring short reaction times.
| Reference Key |
pourmousavi2011e-journalh2so4-silica
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|---|---|
| Authors | ;Seied Ali Pourmousavi;Maryam Hasani |
| Journal | Journal of pharmaceutical and biomedical analysis |
| Year | 2011 |
| DOI |
10.1155/2011/158612
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| URL | |
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