the reaction of cyanoacetylhydrazine with ω-bromo(4-methyl)acetophenone: synthesis of heterocyclic derivatives with antitumor activity
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ID: 130373
2010
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Abstract
New approaches for the synthesis of hydrazide-hydrazone derivatives were demonstrated as well as some heterocyclizations of such derivatives to afford 1,3,4-triazine, pyridine and 1,3,4-oxadiazine derivatives. The antitumor evaluation of the newly synthesized products against three cancer cell lines, namely breast adenocarcinoma (MCF-7), non-small cell lung cancer (NCI-H460) and CNS cancer (SF-268) were recorded. Most of the synthesized compounds showed high inhibitory effects.
| Reference Key |
mohareb2010moleculesthe
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|---|---|
| Authors | ;Rafat M. Mohareb;Abeer A. Mohamed |
| Journal | Journal of ethnopharmacology |
| Year | 2010 |
| DOI |
10.3390/molecules15053602
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