development of antioxidant cox-2 inhibitors as radioprotective agents for radiation therapy—a hypothesis-driven review
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ID: 129906
2016
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Abstract
Radiation therapy (RT) evolved to be a primary treatment modality for cancer patients. Unfortunately, the cure or relief of symptoms is still accompanied by radiation-induced side effects with severe acute and late pathophysiological consequences. Inhibitors of cyclooxygenase-2 (COX-2) are potentially useful in this regard because radioprotection of normal tissue and/or radiosensitizing effects on tumor tissue have been described for several compounds of this structurally diverse class. This review aims to substantiate the hypothesis that antioxidant COX-2 inhibitors are promising radioprotectants because of intercepting radiation-induced oxidative stress and inflammation in normal tissue, especially the vascular system. For this, literature reporting on COX inhibitors exerting radioprotective and/or radiosensitizing action as well as on antioxidant COX inhibitors will be reviewed comprehensively with the aim to find cross-points of both and, by that, stimulate further research in the field of radioprotective agents.
| Reference Key |
laube2016antioxidantsdevelopment
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|---|---|
| Authors | ;Markus Laube;Torsten Kniess;Jens Pietzsch |
| Journal | Frontiers in public health |
| Year | 2016 |
| DOI |
10.3390/antiox5020014
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| URL | |
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