long-term safety in living kidney donors for paediatric transplantation. single-centre prospective study

儿童肾移植活体肾供者的远期安全性。单中心前瞻性研究

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ID: 129829
2016
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Abstract
Introduction: There is enough evidence concerning the short-term safety of living donors after kidney transplantation. However, long-term complications continue to be studied, with a particular interest in young donors. Previous studies have been conducted in older donors for adult renal patients. We present a study of long-term complications in kidney donors for our paediatric population. Methods: We carried out a long-term donor study for the 54 living kidney-donor transplantations performed at our department from 1979 to June 2014. We monitored the glomerular filtration rate (GFR) on the basis of 24-h urine creatinine clearance, 24-h proteinuria and the development of arterial hypertension in the 48 donors who were followed up for more than one year. Only the 39 patients who were exclusively followed up by our department have been included in the results analysis. Results: GFR through creatinine clearance was stable after an initial decrease. No proteinuria was observed in any of the cases. One patient developed chronic kidney disease (CKD), which resulted in a cumulative incidence of 2%. GFR below 60 mL/min/1.73 m2 was not reported in any other patients. Arterial hypertension was diagnosed in 25% of donors, 90% of which were treated with antihypertensives. Conclusions: Risk of CKD and hypertension in living kidney donors for paediatric recipients, who are carefully monitored throughout their evolution, is similar to that of the general population. Therefore, this technique appears to be safe in both the short and long term.
引言：关于肾移植术后活体供者的短期安全性已有充分证据。然而，远期并发症仍有待持续研究，其中针对年轻供者的探讨尤受关注。既往研究多针对为成人肾病患者供肾的年长供者。本研究旨在探讨本中心儿童受者活体肾脏供者的远期并发症。 方法：我们对1979年至2014年6月期间在本科室进行的54例活体供肾肾移植的供者开展了一项远期研究。在随访时间超过1年的48例供者中，我们基于24小时尿肌酐清除率监测了肾小球滤过率（GFR），并监测了24小时尿蛋白以及动脉高血压的发生情况。最终仅纳入完全由本科室随访的39例供者进行结果分析。 结果：基于肌酐清除率评估的GFR在经历初期下降后趋于稳定。所有病例均未见蛋白尿。1例供者进展为慢性肾脏病（CKD），累积发生率为2%。其余供者均未出现GFR低于60 mL/min/1.73 m²的情况。25%的供者被诊断为动脉高血压，其中90%接受了降压药治疗。 结论：在全随访病程中接受严密监测的儿童受者活体肾脏供者中，发生CKD和高血压的风险与普通人群相似。因此，该技术在短期和远期均显示出良好的安全性。
Reference Key
martin2016nefrologalong-term Use this key to autocite in the manuscript while using SciMatic Manuscript Manager or Thesis Manager
Authors Javier Martin, Elena Román, Santiago Mendizabal
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Journal demiryolu mühendisliği
Year 2016
DOI
10.1016/j.nefroe.2016.12.007
URL
http://www.sciencedirect.com/science/article/pii/S2013251416301420
Keywords
kidney transplantation arterial hypertension urology paediatric transplantationdiseases of the genitourinary system

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