synthesis and antimicrobial activities of 1,2,4-triazole and 1,3,4-thiadiazole derivatives of 5-amino-2-hydroxybenzoic acid
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ID: 129419
2008
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Abstract
Various 4-amino-2-[4-(4-substituted phenyl)-5-sulfanyl-4H-1,2,4-triazol-3-yl] phenol (4a-c), 4-amino-2-{4-amino-5-[(4-substituted phenyl)amino]-4H-1,2,4-triazol-3-yl} phenol (5a-c) and 4-amino-2-{5-[(4-substituted phenyl)amino]-1,3,4-thiadiazole-2-yl} phenol (6a-g) were synthesized and evaluated for their antibacterial and antifungal activity. The compounds showed significant antibacterial activity against S. aureus (gram-positive) and E.coli (gram-negative) bacteria and antifungal activity against A. niger fungi using cup plate technique
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| Reference Key |
hussain2008e-journalsynthesis
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|---|---|
| Authors | ;Sabir Hussain;Jyoti Sharma;Mohd Amir |
| Journal | Journal of pharmaceutical and biomedical analysis |
| Year | 2008 |
| DOI |
10.1155/2008/924734
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| URL | |
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