ifn-dependent and -independent reduction in west nile virus infectivity in human dermal fibroblasts

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ID: 129345
2014
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Abstract
Although dermal fibroblasts are one of the first cell types exposed to West Nile virus (WNV) during a blood meal by an infected mosquito, little is known about WNV replication within this cell type. Here, we demonstrate that neuroinvasive, WNV-New York (WNV-NY), and nonneuroinvasive, WNV-Australia (WNV-AUS60) strains are able to infect and replicate in primary human dermal fibroblasts (HDFs). However, WNV-AUS60 replication and spread within HDFs was reduced compared to that of WNV-NY due to an interferon (IFN)-independent reduction in viral infectivity early in infection. Additionally, replication of both strains was constrained late in infection by an IFN-β-dependent reduction in particle infectivity. Overall, our data indicates that human dermal fibroblasts are capable of supporting WNV replication; however, the low infectivity of particles produced from HDFs late in infection suggests that this cell type likely plays a limited role as a viral reservoir in vivo.
Reference Key
hoover2014virusesifn-dependent Use this key to autocite in the manuscript while using SciMatic Manuscript Manager or Thesis Manager
Authors ;Lisa I. Hoover;Brenda L. Fredericksen
Journal International journal of pharmaceutics
Year 2014
DOI
10.3390/v6031424
URL
http://www.mdpi.com/1999-4915/6/3/1424
Keywords
interferon west nile virus intracellular innate immunitymicrobiology

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