reduced oblique effect in children with autism spectrum disorders (asd)

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ID: 129343
2016
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Abstract
People are very precise in the discrimination of a line orientation relative to the cardinal (verti-cal and horizontal) axes, while their orientation discrimination sensitivity along the oblique ax-es is less refined. This difference in discrimination sensitivity along cardinal and oblique axes is called the oblique effect. Given that the oblique effect is a basic feature of visual pro-cessing with an early developmental origin, its investigation in children with Autism Spectrum Disorder (ASD) may shed light on the nature of visual sensory abnormalities frequently report-ed in this population. We examined line orientation sensitivity along oblique and vertical axes in a sample of 26 boys with ASD (IQ > 68) and 38 typically developing (TD) boys aged 7-15 years, as well as in a subsample of carefully IQ-matched ASD and TD participants. Children were asked to detect the direction of tilt of a high-contrast black-and-white grating relative to vertical (90°) or oblique (45°) templates. The oblique effect was reduced in children with ASD as compared to TD participants, irrespective of their IQ. This reduction was due to poor orien-tation sensitivity along vertical axis in ASD children, while their ability to discriminate line orientation along oblique axis was unaffected. We speculate that this deficit in sensitivity to vertical orientation may reflect disrupted mechanisms of early experience-dependent learning that takes place during the critical period for orientation selectivity.
Reference Key
sysoeva2016frontiersreduced Use this key to autocite in the manuscript while using SciMatic Manuscript Manager or Thesis Manager
Authors ;Olga V Sysoeva;Maria A Davletshina;Elena V Orekhova;Ilja A Galuta;Tatiana Alexandrovna Stroganova
Journal Journal of enzyme inhibition and medicinal chemistry
Year 2016
DOI
10.3389/fnins.2015.00512
URL
http://journal.frontiersin.org/Journal/10.3389/fnins.2015.00512/full
Keywords
Children plasticity autism spectrum disorders (asd) critical period neuropsychiatry biological psychiatry visual orientation discriminationneurosciences

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