sister mary joseph′s nodule: a case of umbilical cutaneous metastasis with signet ring cell histology

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ID: 129289
2009
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Ranked #102 of 318 articles by views in crystallization of organic compounds: an industrial perspective

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Abstract
The metastasis of a visceral malignancy to the umbilicus is known as "Sister Mary Joseph′s nodule". It is a rare clinical sign indicating advanced, metastasizing intraabdominal cancer. We report a 50-year-old man who developed metastatic skin cancer in the form of semicircular indurated plaque on top of which was a firm mobile rounded nodule at the umbilical area. Histopathological examination demonstrated diastase-resistant periodic acid-Schiff and mucicarmine positive signet ring cells, suggesting gastric carcinoma. Immunohistochemical staining showed that these cells were positive for cytokeratins and epithelial membrane antigen, suggesting epithelial origin.
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Authors ;Zadeh Valid;Kadyan Randhir;Al-Abdulrazzaq Adel;Al-Otaibi Sultan;Sarhan Amr;Najem Nabeel
Journal crystallization of organic compounds: an industrial perspective
Year 2009
DOI
DOI not found
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http://www.ijdvl.com/article.asp?issn=0378-6323;year=2009;volume=75;issue=5;spage=503;epage=505;aulast=Zadeh
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