alteraÇÕes da matriz extracelular esplÊnica em cÃes naturalmente infectados com leishmania (leishmania) infantum chagasi
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2015
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Abstract
The aim of this study was to study the changes in the splenic extracellular matrix of dogs naturally infected with Leishmania (Leishmania) infantum chagasi and its correlation to clinical,
histopathological, and parasitological aspects. Eighteen dogs were used, separated into three groups: six non-infected animals (control group) and twelve infected animals. The dogs had undefined breed
and age, from the township region of São Luís-MA. Paraffined slices of the spleen were stained with Hematoxilin and Eosin (H&E); Gomori’s ammoniacal Silver, to mark reticular fibers; and the
Immunohistochemistry technique of streptavidin peroxidase to detect amastigote forms of Leishmania. The morphometrical analyses were done using the KS300 program and the images
analysis system Kontron Elektronic/Carl Zeiss, Germany. The results showed that there is a significant increase in the deposition of collagen fibers in the spleen, compared to control animals,
showing significant differences for symptomatic and asymptomatic animals. Positive correlations were found between the presence of the parasite in the tissue and collagen deposition. Symptomatic
animals showed higher collagen deposition in the spleen, which can be associated to the high parasitism found in the tissue. The results showed that there is an intense fibrogenesis in the spleen
in the canine visceral leishmaniasis, thus being associated to the parasitism of the tissue and the degenerative processes of the disease.
| Reference Key |
martins2015cinciaalteraes
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| Authors | ;Nathálya dos Santos Martins;Glaucia Barbosa Coelho;Larissa Sarmento dos Santos;Rudson Almeida de Oliveira;Ana Lúcia Abreu Silva;Ferdinan Almeida Melo |
| Journal | proceedings of the winter simulation conference winter simulation conference |
| Year | 2015 |
| DOI |
10.1590/1089-68916i123500
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| URL | |
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