salivary oxidative stress in oral lichen planus treated with triamcinolone mouthrinse

Clicks: 362
ID: 128948
2017
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Abstract
Background: Total antioxidant capacity (TAC) and malondialdehyde (MDA) levels have not been reported in oral lichen planus (OLP) patients treated with a topical corticosteroid. This study evaluates TAC and MDA levels in unstimulated saliva of OLP patients. Such measurements may need to be supported by clinical observation. Materials and Methods: Twenty patients with OLP participated in a study conducted at the Department of Oral Medicine, Tehran University of Medical Sciences. Salivary TAC and MDA were determined by biochemical analyses before and after 5-week triamcinolone acetonide (0.2%) mouthrinse treatment. Subjective symptoms as well as lesion status pre- and post-treatment were measured using visual analog scale (VAS) and clinical scoring system, respectively. Wilcoxon signed rank test was used for the evaluation of MDA and TAC parameters, VASs, and rates of clinical scores. Spearman's rank correlation was used to determine the relationship between different variables. Results: A statistically significant increase in salivary TAC was found after treatment. There was no significant difference in the reduction of salivary MDA levels in OLP patients after treatment. Conclusion: Posttreatment analyses revealed a significant degree of recovery and pain relief of OLP lesions. Hence, triamcinolon mouthrinse by reducing oxidative stress is an appropriate treatment in OLP patients.
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mansourian2017dentalsalivary Use this key to autocite in the manuscript while using SciMatic Manuscript Manager or Thesis Manager
Authors ;Arash Mansourian;Farzaneh Agha-Hosseini;Hamed Hossein Kazemi;Nazanin Mortazavi;Mahdieh-Sadat Moosavi;Jalil Beytollahi;Iraj Mirzaii-Dizgah
Journal Mycoses
Year 2017
DOI
10.4103/1735-3327.205794
URL
http://www.drjjournal.net/article.asp?issn=1735-3327;year=2017;volume=14;issue=2;spage=104;epage=110;aulast=Mansourian
Keywords
oxidative stress malondialdehyde oral lichen planus

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