detachment and recovery index: a new parameter measuring powder compressibility
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ID: 128345
2010
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Abstract
This investigation introduces a simple and reliable approach to measure the compressibility of some direct compression excipients in tablet systems made from compressible components. The claim made here is that: the total reduction, ΔL T , in the thickness of a tablet batch due to compression at a confined machine settings is the integral sum of small reductions generated by the compressible components in the batch. The reduction value, ΔL E , generated by a single or a blend of excipients in a batch could be calculated and was found to correlate to its concentration, C, by the relation: ΔL E =A E.C x. The constants AE and x concern the reduction tendency, RT, of the excipient particles due to compression, and detachment and recovery index (DRI), respectively. Some physicomechanical parameters characterizing the compression behavior of an excipient in a tablet batch could be determined and were found to be functions of the determine DRI of the excipient in the batch.
| Reference Key |
aly2010journaldetachment
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|---|---|
| Authors | ;SAS Aly |
| Journal | solid state communications |
| Year | 2010 |
| DOI |
10.4103/0110-5558.76440
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| URL | |
| Keywords | Keywords not found |
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