Zn- or Cu-containing CaP-Based Coatings Formed by Micro-Arc Oxidation on Titanium and Ti-40Nb Alloy: Part II-Wettability and Biological Performance.

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2020
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Abstract
This work describes the wettability and biological performance of Zn- and Cu-containing CaP-based coatings prepared by micro-arc oxidation on pure titanium (Ti) and novel Ti-40Nb alloy. Good hydrophilic properties of all the coatings were demonstrated by the low contact angles with liquids, not exceeding 45°. An increase in the applied voltage led to an increase of the coating roughness and porosity, thereby reducing the contact angles to 6° with water and to 17° with glycerol. The free surface energy of 75 ± 3 mJ/m for all the coatings were determined. Polar component was calculated as the main component of surface energy, caused by the presence of strong polar PO and OH bonds. In vitro studies showed that low Cu and Zn amounts (~0.4 at.%) in the coatings promoted high motility of human adipose-derived multipotent mesenchymal stromal cells (hAMMSC) on the implant/cell interface and subsequent cell ability to differentiate into osteoblasts. In vivo study demonstrated 100% ectopic bone formation only on the surface of the CaP coating on Ti. The Zn- and Cu-containing CaP coatings on both substrates and the CaP coating on the Ti-40Nb alloy slightly decreased the incidence of ectopic osteogenesis down to 67%. The MAO coatings showed antibacterial efficacy against and can be arranged as follows: Zn-CaP/Ti > Cu-CaP/TiNb, Zn-CaP/TiNb > Cu-CaP/Ti.
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Authors Komarova, Ekaterina G;Sharkeev, Yurii P;Sedelnikova, Mariya B;Prymak, Oleg;Epple, Matthias;Litvinova, Larisa S;Shupletsova, Valeria V;Malashchenko, Vladimir V;Yurova, Kristina A;Dzyuman, Anna N;Kulagina, Irina V;Mushtovatova, Lyudmila S;Bochkareva, Olga P;Karpova, Mariia R;Khlusov, Igor A;
Journal Materials (Basel, Switzerland)
Year 2020
DOI
E4366
URL
Keywords
biocompatibility micro-arc oxidation ti-40wt.%nb alloy antibacterial efficacy bone lamellae calcium phosphate coating ectopic bone formation wettability

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