A closer look at the role of insulin for the regulation of male reproductive function.

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ID: 127927
2020
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Ranked #6 of 12 articles by views in general and comparative endocrinology

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Abstract
While insulin demonstrates to have a considerable influence on the reproductive system, there are various unanswered questions regarding its precise sites, mechanisms of action, and roles for the developing and functioning of the adult male reproductive system. Apart from its effects on glucose level, insulin has an important role in the reproductive system directly by binding on insulin and IGF receptors in the brain and testis. To date, however, the effect of insulin or its alterations on blood-testis-barrier, as an important regulator of normal spermatogenesis and fertility, has not yet been studied. This review aimed to focus on the experimental and clinical studies to describe mechanisms by which insulin affects the hypothalamic-pituitary-gonadal (HPG) axis, testicular cells, spermatozoa, and sexual behavior. Moreover, we discussed the mechanism and impact of insulin changes in type 1 (insulin deficiency along with persisted or even increased sensitivity) and 2 (insulin resistance along with increased insulin level at the early stages of disease) diabetes and obesity on the male reproductive tract.
Reference Key
oghbaei2020ageneral Use this key to autocite in the manuscript while using SciMatic Manuscript Manager or Thesis Manager
Authors Oghbaei, Hajar;Fattahi, Amir;Hamidian, GholamReza;Sadigh-Eteghad, Saeed;Ziaee, Mojtaba;Mahmoudi, Javad;
Journal general and comparative endocrinology
Year 2020
DOI
S0016-6480(20)30396-8
URL
Keywords
spermatogenesis insulin fertility male gonadotropin-releasing hormone hypothalamic-pituitary-gonadal axis

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