Ir-6: A Novel Iridium (III) Organometallic Derivative for Inhibition of Human Platelet Activation
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2018
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Abstract
Platelet activation has been reported to play a major role in arterial thrombosis, cancer metastasis, and progression. Recently, we developed a novel Ir(III)-based compound, [Ir(Cp)1-(2-pyridyl)-3-(4-dimethylaminophenyl)imidazo[1,5-a]pyridine Cl]BF4 or Ir-6 and assessed its effectiveness as an antiplatelet drug. Ir-6 exhibited higher potency against human platelet aggregation stimulated by collagen. Ir-6 also inhibited ATP-release, intracellular Ca2
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| Reference Key |
renshi2018ir6bioinorganic
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| Authors | Shyu, Ren-Shi;Khamrang, Themmila;Sheu, Joen-Rong;Hsia, Chih-Wei;Velusamy, Marappan;Hsia, Chih-Hsuan;Chou, Duen-Suey;Chang, Chao-Chien;Shyu, Ren-Shi;Khamrang, Themmila;Sheu, Joen-Rong;Hsia, Chih-Wei;Velusamy, Marappan;Hsia, Chih-Hsuan;Chou, Duen-Suey;Chang, Chao-Chien; |
| Journal | bioinorganic chemistry and applications |
| Year | 2018 |
| DOI |
10.1155/2018/8291393
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| URL | |
| Keywords | Keywords not found |
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