Current Developments in Pt(IV) Prodrugs Conjugated with Bioactive Ligands

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ID: 12175
2018
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Abstract
To overcome the side effects of and resistance to cisplatin, a variety of Pt(IV) prodrugs were designed and synthesized via different modifications including combination with lipid chains to increase hydrophobicity, conjugation with short peptide chains or nanoparticles to improve drug delivery, or addition of bioactive ligands to the axial positions of Pt(IV) complexes to exert dual-function effects. This review summarizes the recent progress in the development of Pt(IV) prodrugs conjugated with bioactive-targeting ligands, including histone deacetylase inhibitors, p53 agonists, alkylating agents, and nonsteroidal anti-inflammatory agents. Although Pt(IV) complexes that conjugated with bioactive ligands show satisfactory anticancer effects, none has been approved for clinical use. Therefore, we hope that this review will contribute to further study and development of Pt(IV) complexes conjugated with bioactive and other ligands.
Reference Key
xuejiao2018currentbioinorganic Use this key to autocite in the manuscript while using SciMatic Manuscript Manager or Thesis Manager
Authors Li, Xuejiao;Liu, Yahong;Tian, Hongqi;Li, Xuejiao;Liu, Yahong;Tian, Hongqi;
Journal bioinorganic chemistry and applications
Year 2018
DOI
10.1155/2018/8276139
URL
https://www.hindawi.com/journals/bca/2018/8276139/abs/
Keywords Keywords not found

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