Recent advances in the development of cyclin-dependent kinase 7 inhibitors

Clicks: 405
ID: 121460
2019
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Abstract
Cyclin dependent kinase 7 (CDK7) plays a double role as it activates several other cyclin dependent kinases and participates to the initiation of transcription. This kinase is overexpressed in various types of tumors. Relatively few selective CDK7 inhibitors have been up to now disclosed. Most of th …
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Authors Teng Y;Lu K;Zhang Q;Zhao L;Huang Y;Ingarra AM;Galons H;Li T;Cui S;Yu P;Oumata N;;
Journal European journal of medicinal chemistry
Year 2019
DOI
DOI not found
URL
https://www.pubmed.gov/31514062/
Keywords
Tumor National Center for Biotechnology Information NCBI NLM MEDLINE review animals humans pubmed abstract nih national institutes of health national library of medicine cell line cell survival / drug effects protein kinase inhibitors / pharmacology pmid:31514062 doi:10.1016/j.ejmech.2019.111641 yuou teng kui lu nassima oumata antineoplastic agents / chemistry* antineoplastic agents / pharmacology cyclin-dependent kinases / antagonists & inhibitors* drug development protein kinase inhibitors / chemistry* pyrimidines / chemistry* pyrimidines / pharmacology triazines / chemistry* triazines / pharmacology

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