Prenatal androgen excess negatively impacts body fat distribution in a nonhuman primate model of polycystic ovary syndrome
Clicks: 281
ID: 121220
2007
Article Quality & Performance Metrics
Overall Quality
Improving Quality
0.0
/100
Combines engagement data with AI-assessed academic quality
Reader Engagement
Star Article
78.9
/100
276 views
222 readers
Trending
AI Quality Assessment
Not analyzed
Abstract
Prenatally androgenized (PA) female rhesus monkeys share metabolic abnormalities in common with polycystic ovary syndrome (PCOS) women. Early gestation exposure (E) results in insulin resistance, impaired pancreatic β-cell function and type 2 diabetes, while late gestation exposure (L) results in supranormal insulin sensitivity that declines with increasing body mass index (BMI). To determine whether PA females have altered body fat distribution. Five early-treated PA (EPA), five late-treated PA (LPA) and five control adult female monkeys underwent somatometrics, dual-X-ray absorptiometry (DXA) and abdominal computed tomography (CT). Five control and five EPA females underwent an intravenous glucose tolerance test to assess the relationship between body composition and glucoregulation. There were no differences in age, weight, BMI or somatometrics. LPA females had ∼20% greater DXA-determined total fat and percent body fat, as well as total and percent abdominal fat than EPA or control females (P⩽0.05). LPA females also had ∼40% more CT-determined non-visceral abdominal fat than EPA or control females (P⩽0.05). The volume of visceral fat was similar among the three groups. EPA (R2=0.94, P⩽0.01) and LPA (R2=0.53, P=0.16) females had a positive relationship between visceral fat and BMI, although not significant for LPA females. Conversely, control females had a positive relationship between non-visceral fat and BMI (R2=0.98, P⩽0.001). There was a positive relationship between basal insulin and total body (R2=0.95, P⩽0.007), total abdominal (R2=0.81, P⩽0.04) and visceral (R2=0.82, P⩽0.03) fat quantities in EPA, but not control females. Prenatal androgenization in female rhesus monkeys induces adiposity-dependent visceral fat accumulation, and late gestation androgenization causes increased total body and non-visceral fat mass. Early gestation androgenization induces visceral fat-dependent hyperinsulinemia. The relationship between the timing of prenatal androgen exposure and body composition phenotypes in this nonhuman primate model for PCOS may provide insight into the heterogeneity of metabolic defects found in PCOS women.
Abstract Quality Issue:
This abstract appears to be incomplete or contains metadata (295 words).
Try re-searching for a better abstract.
| Reference Key |
bruns2007internationalprenatal
Use this key to autocite in the manuscript while using
SciMatic Manuscript Manager or Thesis Manager
|
|---|---|
| Authors | C M Bruns;S T Baum;R J Colman;D A Dumesic;J R Eisner;M D Jensen;L D Whigham;D H Abbott;C M Bruns;S T Baum;R J Colman;D A Dumesic;J R Eisner;M D Jensen;L D Whigham;D H Abbott; |
| Journal | international journal of obesity |
| Year | 2007 |
| DOI |
doi:10.1038/sj.ijo.0803638
|
| URL | |
| Keywords |
Citations
No citations found. To add a citation, contact the admin at info@scimatic.org
Comments
No comments yet. Be the first to comment on this article.