Evaluation of the antiviral activity of N-(phosphonoacetyl)-L-aspartate against paramyxoviruses in tissue culture and against respiratory syncytial virus in cotton rats

Clicks: 358
ID: 120657
1995
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Abstract
N-(phosphonoacetyl)-L-aspartate (PALA), a potent inhibitor of L-aspartic acid transcarbamoylase, was evaluated for cytotoxicity and antiviral activity against three different paramyxoviruses in tissue culture, and for antiviral efficacy and toxicity in vivo using a cotton rat-respiratory syncytial v …
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Authors Wyde PR;Moore DK;Pimentel DM;Blough HA;;
Journal Antiviral research
Year 1995
DOI
DOI not found
URL
http://www.ncbi.nlm.nih.gov/pubmed/7486959
Keywords
National Center for Biotechnology Information NCBI NLM MEDLINE animals pubmed abstract nih national institutes of health national library of medicine female male Cultured Rats p r wyde d k moore evaluation studies as topic sigmodontinae dogs chlorocebus aethiops respiratory syncytial viruses / drug effects* vero cells antiviral agents / pharmacology* human / drug effects molecular structure tumor cells parainfluenza virus 3 pmid:7486959 doi:10.1016/0166-3542(94)00080-r h a blough aspartic acid / analogs & derivatives* aspartic acid / pharmacology measles virus / drug effects phosphonoacetic acid / analogs & derivatives* phosphonoacetic acid / pharmacology respirovirus / drug effects* toxicity tests

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