An Antibody Designed to Improve Adoptive NK-Cell Therapy Inhibits Pancreatic Cancer Progression in a Murine Model

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ID: 120634
2019
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Abstract
Natural killer (NK) cells are primary immune cells that target cancer cells and can be used as a therapeutic agent against pancreatic cancer. Despite the usefulness of NK cells, NK-cell therapy is limited by tumor cell inhibition of NK-cell homing to tumor sites, thereby preventing a sustained antit …
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Authors Lee J;Kang TH;Yoo W;Choi H;Jo S;Kong K;Lee SR;Kim SU;Kim JS;Cho D;Kim J;Kim JY;Kwon ES;Kim S;;
Journal cancer immunology research
Year 2019
DOI
DOI not found
URL
https://www.pubmed.gov/30514792/
Keywords
Tumor National Center for Biotechnology Information NCBI NLM MEDLINE Mice animals humans pubmed abstract nih national institutes of health national library of medicine treatment outcome research support non-u.s. gov't female Disease Models Animal Antibodies cell line immunotherapy monoclonal / pharmacology* combined modality therapy disease progression pancreatic neoplasms / pathology pmid:30514792 doi:10.1158/2326-6066.cir-18-0317 jaemin lee tae heung kang seokho kim chemotaxis / drug effects chemotaxis / immunology immunoconjugates / pharmacology adoptive* / methods killer cells natural / immunology* natural / metabolism pancreatic neoplasms / immunology* pancreatic neoplasms / mortality pancreatic neoplasms / therapy* xenograft model antitumor assays

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