Respiratory syncytial virus infections in autologous blood and marrow transplant recipients with breast cancer: combination therapy with aerosolized ribavirin and parenteral immunoglobulins

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ID: 120570
2001
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Abstract
Scant data are available concerning the impact and response to therapy of respiratory syncytial virus (RSV) infections in patients undergoing autologous blood and marrow transplantation (BMT) for breast cancer. During eight winter seasons from 1992–1993 to 1999–2000, nine (4%) of 249 such patients were hospitalized with RSV infections. Six patients, including all five patients who were early post transplant in the pre-engraftment period, developed pneumonia and were treated with a combination of aerosolized ribavirin and IVIG. Among five patients with pneumonia in whom therapy was initiated prior to respiratory failure, one (20%) died. The sixth patient, in whom therapy was initiated after respiratory failure developed, also died. In total, two (1%) patients, both of whom were in the pre-engraftment period, died of progressive pneumonia. In conclusion, RSV is a significant cause of life-threatening pneumonia in autologous BMT recipients with breast cancer during the early post-transplant period, and accounted for a substantial portion of the overall transplant-related mortality, which in recent years has been minimal. Bone Marrow Transplantation (2001) 28, 271–275.
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ghosh2001bonerespiratory Use this key to autocite in the manuscript while using SciMatic Manuscript Manager or Thesis Manager
Authors S Ghosh;RE Champlin;NT Ueno;P Anderlini;K Rolston;I Raad;D Kontoyiannis;K Jacobson;M Luna;J Tarrand;E Whimbey;S Ghosh;RE Champlin;NT Ueno;P Anderlini;K Rolston;I Raad;D Kontoyiannis;K Jacobson;M Luna;J Tarrand;E Whimbey;
Journal bone marrow transplantation
Year 2001
DOI
doi:10.1038/sj.bmt.1703131
URL
http://dx.doi.org/10.1038/sj.bmt.1703131
Keywords
cell biology public health stem cells internal medicine hematology general medicine/public health

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