Inhibition of respiratory syncytial virus replication by antisense oligodeoxyribonucleotides

Clicks: 415
ID: 120446
1997
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Abstract
Oligodeoxyribonucleotides targeted against respiratory syncytial virus (RSV) genomic RNA inhibited RSV replication in cell culture by an apparent antisense mechanism. HEp-2 cells were infected with RSV strain A2 and incubated in the presence of oligonucleotides. Virus replication was measured by enz …
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Authors Jairath S;Vargas PB;Hamlin HA;Field AK;Kilkuskie RE;;
Journal Antiviral research
Year 1997
DOI
DOI not found
URL
http://www.ncbi.nlm.nih.gov/pubmed/9037376
Keywords
National Center for Biotechnology Information NCBI NLM MEDLINE RNA humans pubmed abstract nih national institutes of health national library of medicine Cultured Antigens DNA genome Base Sequence Viral Molecular Sequence Data respiratory syncytial viruses / growth & development viral / biosynthesis hn protein* viral envelope proteins respiratory syncytial viruses / drug effects* antiviral agents / pharmacology* respiratory syncytial viruses / physiology cell division / drug effects respiratory syncytial viruses / genetics tumor cells antiviral agents / toxicity virus replication / drug effects antisense / pharmacology* oligonucleotides viral proteins / biosynthesis pmid:9037376 doi:10.1016/s0166-3542(96)01015-7 s jairath p b vargas r e kilkuskie antisense / toxicity

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